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KMID : 1234920180180010019
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Journal of Korean Oriental Association for Study of Obesity
2018 Volume.18 No. 1 p.19 ~ p.26
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The Effects of Scutellaria Radix Extract on the Alcohol-Induced Fatty Acid Synthesis of Liver in Rats
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Kim Bum-Hoi
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Abstract
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Objectives: Alcoholic fatty liver is a potentially pathologic condition which can progress to steatohepatitis, fibrosis, and cirrhosis. The objective of this study is to investigate the effects of Scutellaria Radix (SR) extract on the alcoholic fatty liver induced by long-term EtOH administration.
Results: Male Sprague Dawley rats were used in this study. All animals were randomly divided into Normal group, treated with saline (n=10); EtOH group, treated with ethanol (n=10); EtOH+SR group, treated with ethanol+Scutellaria Radix extract (n=10). For oral administration of ethanol in EtOH and EtOH+SR group, the ethanol was dissolved in distilled water in concentrations of 25% (v/v). Throughout the experiment of 8 week, the rats were allowed free access to water and standard chow. Sample group were administrated by Scutellaria Radix extract daily for 8 weeks.
Results: The levels of hepatic marker such as aspartate aminotransferase and alanine aminotransferase were altered. Histopathological changes such as ballooning, fatty and hydropic degeneration were reduced and the expression of tumor necrosis factor-α (TNF-α) was significantly attenuated by Scutellaria Radix extract.
Conclusions: These data suggest that Scutellaria Radix extract attenuated the alcoholic simple fatty liver by improving hepatic lipid metabolism via suppression of TNF-α protein. Scutellaria Radix could be effective in protecting the liver from alcoholic fatty liver.
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KEYWORD
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Alcoholic fatty liver, Scutellaria Radix, TNF-α, AST, ALT
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